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The U.S. is “going in the wrong direction” with the coronavirus surging badly enough that Dr. Anthony Fauci told senators Tuesday some regions are putting the entire country at risk — just as schools and colleges are wrestling with how to safely reopen.

With about 40,000 new cases being reported a day, Fauci, the government’s top infectious disease expert, said he “would not be surprised if we go up to 100,000 a day if this does not turn around.

“I am very concerned,” he told a hearing of the Senate Health, Education, Labor and Pensions committee.

Infections are rising rapidly mostly in parts of the West and South, and Fauci and other public health experts said Americans everywhere will have to start following key recommendations if they want to get back to more normal activities like going to school.

“We’ve got to get the message out that we are all in this together,” by wearing masks in public and keeping out of crowds, said Fauci, infectious disease chief at the National Institutes of Health.

Connect the dots, he told senators: When and how school buildings can reopen will vary depending on how widely the coronavirus is spreading locally.

“I feel very strongly we need to do whatever we can to get the children back to school,” he said.

The Centers for Disease Control and Prevention plans more guidelines for local school systems, Director Robert Redfield said.

But in recommendations for colleges released Tuesday, the agency said it won’t recommend entry testing for all returning students, faculty and staff. It’s not clear if that kind of broad-stroke testing would reduce spread of the coronavirus, CDC concluded. Instead, it urged colleges to focus on containing outbreaks and exposures as students return.

Lawmakers also pressed for what Sen. Patty Murray of Washington, the committee’s top Democrat, called a national vaccine plan — to be sure the race for the COVID-19 vaccine ends with shots that really are safe, truly protect and are available to all Americans who want, one.

“We can’t take for granted this process will be free of political influence,” Murray said. She cited how President Donald Trump promoted a malaria drug as a COVID-19 treatment that ultimately was found to be risky and ineffective.

The Food and Drug Administration released guidelines Tuesday saying any vaccine that wins approval will have to be at 50% more effective than a dummy shot in the final, required testing. That’s less effective than many of today’s vaccines but independent experts say that would be a good start against the virus.

FDA Commissioner Stephen Hahn said vaccine makers also must test their shots in diverse populations, including minorities, the elderly, pregnant women and those with chronic health problems.

“We will not cut corners in our decision-making,” Hahn told senators.

About 15 vaccine candidates are in various stages of human testing worldwide but the largest studies — including 30,000 people each — needed to prove if a shot really protects are set to begin in July. First up is expected to be a vaccine created by the NIH and Moderna Inc., followed closely by an Oxford University candidate.

At the same time, the Trump administration’s “Operation Warp Speed” aims to stockpile hundreds of millions of doses by year’s end, so they could rapidly start vaccinations if and when one is proven to work.

Redfield said the CDC already is planning how to prioritize who is first in line for the scarce first doses and how they’ll be distributed.

But a vaccine is at the very least many months away. For now, the committee’s leading Republican stressed wearing a mask — and said Trump, who notoriously shuns them, needs to start because politics is getting in the way of protecting the American people.

“The stakes are too high for the political debate about pro-Trump, anti-Trump masks to continue,” said Sen. Lamar Alexander of Tennessee, who chaired Tuesday’s hearing.

Alexander said he had to self-quarantine after a staff member tested positive for the virus but that he personally was protected because his staffer was wearing a mask.

“The president has plenty of admirers. They would follow his lead,” Alexander said. “The stakes are too high” to continue that fight.


AP writers Ricardo Alonso-Zaldivar and Matthew Perrone in Washington, Collin Binkley in Boston and Mike Stobbe in New York contributed to this report.


The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

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'They Needed People': Brazil Volunteers Step up to Test COVID-19 Vaccine

By Eduardo Simões

SAO PAULO (Reuters) - Luiz Augusto Rizzo, 29, is no specialist in infectious diseases, but he is part of perhaps the most important scientific endeavor in the world today: the hunt for a vaccine against the novel coronavirus.

The pediatric surgeon is one of 2,000 volunteers in Brazil's largest city of Sao Paulo taking part in mass human trials for the experimental coronavirus vaccine developed by researchers at the University of Oxford and AstraZeneca Plc (AZN.L). It is one of the brightest hopes in the global bid to contain the virus.

Developers and researchers are looking to places like Brazil, where the new coronavirus is still spreading fast, to test potential vaccines.

With nearly 1.9 million cases, Brazil has the world's second-worst outbreak behind only the United States. More than 72,000 people have died of COVID-19, the disease caused by the virus, in Brazil.

"They needed people," Rizzo told Reuters via video call.

Hospital colleagues who specialize in infectious diseases had explained the importance of the trials to him.

"There probably won't be a cure... They said the only way (to beat the virus) is to have a vaccine, and you need to test, you need to make the most of those who are healthy, those who are able to tick all the boxes needed to participate," he said.

So-called Phase III trials, involving thousands of human volunteers, began last month in Brazil for the Oxford vaccine.

Volunteers have to record their temperature once a day, fill in an online diary about their condition and attend periodic consultations. Participants, who will be monitored of a year, do not know if they have been given the vaccine or a placebo.

Hematologist Vinicius Molla, 33, who frequently conducts clinical studies in his own area, also wanted to help.

"I do clinical trials, I know the difficulty of getting volunteers to participate," he said.

(Reporting by Eduardo Simoes, writing by Stephen Eisenhammer; Editing by Bernadette Baum)

Copyright 2020 Thomson Reuters.

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