Aug 02, 2020
Researchers find key to cure blindness
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test It has been led by Dr. David Gamm and has been published in the American Journal of Human Genetics and this line of work could lead to healing an incurable disease. “data-reactid =” 12 “> A team of researchers from the University of Wisconsin-Madison have published a paper trial to cure blindness from hereditary macular degeneration, a condition that was not curable to date.The trial has been led by Dr. David Gamm and has It has been published in the American Journal of Human Genetics and this line of work could give way to cure an incurable disease.
blindness total over the course of a few decades. This disease has a clear hereditary component and is caused by more than 2,000 mutations of the BEST1 gene. “Data-reactid =” 24 “> Specifically, the team has focused on vitelliform macular dystrophy, also known as BEST disease , and which causes a gradual loss of vision from childhood to total blindness over the course of a few decades.This disease has a clear hereditary component and is caused by more than two thousand mutations of the BEST1 gene.
mutations that have been tested, but not in all, as the team itself highlights. Specifically, the work has been based on the application of the CRISPR-Cas9 gene in the mutated genes. “Data-reactid =” 25 “> Researchers have approached this incurable disease in a different way from those proposed to date: they have corrected degeneration by placating the mutated genes with functional copies of BEST1. This approach has been successful in most, but not all, of the mutations that have been tested. Specifically, the work has been based on the application of the CRISPR-Cas9 gene in the mutated genes.
genetics requires high precision when substituting faulty genes for functional ones, as highlighted in the trial. “data-reactid =” 26 “> What is the origin of Best’s disease? The BEST1 gene contains a protein that It affects a layer of the retina known as RPE, so that by inheriting this defective gene from one of the parents, the person will be affected by this disease and will be doomed to blindness. This gene therapy requires high precision to when substituting faulty genes for functional ones, as highlighted in the trial.
Are we close to the cure for Best’s disease? The short answer is no, but the hope is that, in theory, a new avenue has been opened to apply healing to real patients. “We were able to reduce disease across the gene lines,” confirms Gamm, and the good news does not end here: This approach to the problem could be applied to other diseases caused by genetic mutations that affect tissues.
Researchers find key to cure blindness appeared first on Digital Trends Spanish. “data-reactid =” 28 “> The post Researchers find a key to cure blindness appeared first on Digital Trends Spanish.
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The best British series on Netflix
Nordic Noir, English series are almost a genre unto themselves. “data-reactid =” 12 “> In a variety of genres, from black comedy to police dramas, the following are some of the best British series on Netflix. We are not exaggerating when We say that many of them are at the top in terms of narrative, originality and recognized quality, and it is that as with Nordic Noir, English series are almost a genre in itself.Monty Python’s Flying Circus (1969)
Netflix“data-reactid =” 23 “> NetflixCrashing (2016)
Netflix“data-reactid =” 34 “> NetflixCollateral (2018)
Netflix“data-reactid =” 49 “> NetflixTop Boy (2011)
Netflix“data-reactid =” 60 “> NetflixBroadchurch (2013)
Netflix“data-reactid =” 71 “> NetflixThe Great British Baking Show (2010)
Netflix“data-reactid =” 82 “> NetflixPeaky Blinders (2013)
This crime drama set in Birmingham, England, follows the story of the Shelby crime family after World War I. The story is a free adaptation of the story of the true 19th century gang of the same name, and stars Cillian Murphy as leader Tommy Shelby. Five seasons have aired so far, all of which are available on Netflix. The series has been highly praised for its story and good narrative pacing, with an excellent script, brilliant performances, and impeccable photography.
Netflix“data-reactid =” 93 “> NetflixSex Education (2019)
Released in January 2019, this British drama has been called heartfelt and surprisingly wise. Asa Butterfield stars as a somewhat maladaptive and ambivalent teenager about sex, this in large part because her mother (Gillian Anderson) is an accomplished sex therapist. Netflix said the series had more than 40 million viewers after its launch; The second season debuted on January 17, 2020 with a total of 16 episodes that you can enjoy right now.
Netflix“data-reactid =” 104 “> NetflixBodyguard (2018)
Netflix“data-reactid =” 115 “> NetflixSherlock (2010)
This crime drama starring Benedict Cumberbatch, Martin Freeman and Rupert Graves has only grown stronger over its four seasons. Centered on the life of detective Sherlock Holmes and based on a modern take on the Sir Arthur Conan Doyle stories, Cumberbatch plays the title character and Freeman plays his partner, Dr. John Watson. While most of the series has Holmes in the modern era, his special narrative takes us back to the Victorian period. With its star-studded cast and compelling story, it’s no surprise that it has received hundreds of critical acclaim.
Netflix“data-reactid =” 126 “> NetflixLovesick (2016)
Netflix“data-reactid =” 137 “> NetflixBlack Mirror (2011)
While Black Mirror eventually became known as a “Netflix original” series, Charlie Booker’s brilliant dystopia first premiered on Channel 4 in the UK. Most of the episodes analyze the worst scenarios of our relationship with technology and the modern dependence we have on it. With five seasons to date, this is not the type of series you will be able to quickly watch. The good news is that you can watch it in any order, and we guarantee that your jaw will drop at the end of each episode.
Netflix“data-reactid =” 148 “> Netflix
Amazon prime& nbsp; | Hulu | Disney Plus |HBO | Netflix“data-reactid =” 149 “>More streaming: Amazon Prime | Hulu | Disney Plus | HBO | Netflix